(1) Reuss, J.M.; Alonso-Gamo,L.; Garcia-Aranda, M.; Reuss, D.; Albi, M.; Albi, B.; Vilaboa, D.; Vilaboa, B. Oral Mucosa in Cancer Patients—Putting the Pieces Together: A Narrative Review and New Perspectives. Cancers 2023, 15, 3295
Saliactive®
Saliactive® Technology has been developed after years of clinical research to improve the field of health and well-being of people.
Our current lifestyles, the increase in longevity, the desire to have an active and healthy life for more years has driven us at Mucosa Innovations to carry out clinical research in three main fields:
The cancer patient
Women’s health
The human microbiome
As a result of these lines of research, Mucosa Innovations has obtained patents in the field of mucositis, genitourinary syndrome and dysbiosis and has developed specific product lines in the three fields.
Saliactive® is a patented composition that includes top quality natural ingredients such as extra virgin olive oil, xylitol and betaine.
The mucosa and human skin are the largest organs in the body and exert a barrier function against pathogens, allergens and toxic substances. In addition, they perform essential functions for our health, and are the main habitat for the human microbiome.
A weakened, inflamed or brittle mucosa or skin cannot provide us with this barrier function, leaving us exposed, altering our microbiome and, therefore, our health.
Recently clinical investigations with the highest scientific level have demonstrated the efficacy of the Saliactive® composition to correct the imbalance of the oral microbiome, maintain the necessary conditions for health and reduce bleeding through non-antibacterial mechanisms, by reinforcing the oral ecosystem itself.
Fields of application
The benefits of Saliactive® technology are multiple in cancer patients(1), even in cases of head and neck cancer exposed to radiotherapy or chemotherapy. (2)
The health of women both in the postmenopausal period and in breast cancer survivors is in our focus of research with clinical studies in these fields. (3)
Saliactive® helps patients with oral dysbiosis with phase 2 – phase 3 studies demonstrating efficacy in the microbiome field. (4) (5)
Saliactive® has been shown to increase salivary flow, reduce symptoms related to Xerostomia and dry mouth, and improve quality of life. (6)
Scientific evidence
Important scientific studies have shown that Saliactive ® Technology cares for the oral mucosa and microbiome, providing great benefits to human health and improving people’s quality of life.
(2) Martín M, Marín A, López M, Liñán O, Alvarenga F, Büchser D, Cerezo L. Products based on olive oil, betaine, and xylitol in the post-radiotherapy xerostomia. Rep Pract Oncol Radiother. 2017 Jan-Feb;22(1):71-76.
(3) Cañadas Molina, A et al. A Laser and Topical Treatment Combination in the Vulvo-vaginal Atrophy Management in Breast Cancer Patients. ClinicalTrials.gov Identifier: NCT05585476.
(4) Mesa Aguado, Francisco Luis. Study on the Effects of a Toothpaste in the Microbiome and Clinical Parameters in Patients With Oral Dysbiosis. ClinicalTrials.gov Identifier: NCT05463484.
(5) Rodríguez-Agurto, A., Bravo, M., Magán-Fernandez, A. et al. Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis. Sci Rep 13, 6294 (2023). nature.com.
(6) Ship JA, McCutcheon JA, Spivakovsky S, Kerr AR. Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J Oral Rehabil. 2007 Oct;34(10):724-32.
AOVE (Aceite de oliva virgen extra)
Es un antimicrobiano que aporta polifenoles naturales con acción antioxidante. Además, posee una gran actividad prebiótica.
Xilitol
Es un edulcorante natural que se extrae de los abedules. Su índice glucémico es muy bajo, por lo que es apto para personas con diabetes.
Estudios científicos han demostrado que además de ser anticariogénico tiene actividad prebiótica de la mucosa oral.
Betaína o Trimetilglicina
Es un derivado aminoácido obtenido a partir de la remolacha, posee actividad hidratante y antioxidante, protege la mucosa oral y es un antiinflamatorio natural.
